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KMID : 0359320230630020008
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Korean Journal of Veterinary Research
2023 Volume.63 No. 2 p.8 ~ p.8
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Experimental infection of a porcine kidney cell line with hepatitis A virus
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Kim Dong-Hwi
Kim Da-Yoon
Kim Jae-Hyeong
Lim Kyu-Beom
Lee Joong-Bok
Park Seung-Yong
Song Chang-Seon
Lee Sang-Won
Choi In-Soo
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Abstract
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The hepatitis A virus (HAV) induces severe acute liver injury and is adapted to human and monkey cell lines but not other cells. In this study, the HAV was inoculated into porcine kidney (PK-15) cells to determine its infectivity in porcine cells. The growth pattern of the HAV in PK-15 cells was compared with its growth pattern in fetal rhesus kidney (FRhK-4) cells. The growth of HAV was less efficient in PK-15 cells. In conclusion, HAV replication was verified in PK-15 cells for the first time. Further investigations will be needed to identify the HAV-restrictive mechanisms in PK-15 cells.
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KEYWORD
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hepatitis A virus, humans, swine, cells, replication
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